초기임상시험 전문 의료진

초기임상시험 및 임상약리연구에 대한 최적화된 서비스 제공 합니다.

초기임상시험 및 임상약리연구에 대한 전문의료진

조두연 교수

임상약리학과/가정의학과

상세소개
연구분야
신약임상개발, 초기임상시험, 건강기능성식품 인체적용시험, 약물유전체학, 특수집단약물요법,
맞춤약물요법, 약물이상반응
연구경험
  • Drug-drug interaction studies
  • Comparative pharmacokinetic studies
  • First-in-Human Studies (Alzheimer’s disease, Fatigue)
  • Gastric pH monitoring studies
  • Genotype-based PK/PD studies
주요연구 실적
SCI 논문 37편(주저자 12편)
  • W Shin, MK Kim, DY Cho. Pharmacokinetic study of two extended-release formulations of cilostazol in healthy Korean volunteers: A randomized, open-label, multiple-dose, two-period crossover study. Int J Clin Pharmacol Ther. 2019. In press.
  • Shin W, Lim KS, Kim MK, Kim HS, Hong J, Jhee S, Kim J, Yoo S, Chung YT, Lee JM, Cho DY. A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers. Drug Des Devel Ther. 2019;13:1011-1022
  • Kim KN, Yang SW, Kim H, Kwak SS, Kim YS, Cho DY. Acid Inhibitory Effect of a Combination of Omeprazole and Sodium Bicarbonate (CDFR0209) Compared With Delayed-Release Omeprazole 40 mg Alone in Healthy Adult Male Subjects. Clin Pharmacol Drug Dev. 2018; 7(1):53-58.
  • Cho DY, Shen JH, Lemler SM, Skaar TC, Li L, Blievernicht J, Zanger UM, Kim KB, Shin JG, Flockhart DA, Desta Z. Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers. Drug Metab Pharmacokinet. 2016;31(2):107-16.
  • Oh M, Yoon J, Cho DY. Pharmacokinetic and Pharmacodynamic Comparison of Two Recombinant Human Erythropoietin Formulations, PDA10 and Eprex, in Healthy Korean Male Volunteers: A Randomized, Double-Blinded, Single-Dose, Two-Period Crossover Study. Clin Drug Investig. 2015; 35(10):659-64.
  • Cho DY, Bae SH, Lee JK, Park JB, Kim YW, Lee S, Oh E, Kim BT, Bae SK. Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers. 2015;45(3):256-63.

김언혜교수

임상약리학과

상세소개
연구분야
신약임상개발, 초기임상시험, 마이크로도즈 임상시험, 실용임상시험 (Pragmatic clinical trial), 맞춤약물요법
연구경험
  • First-in-human studies (Dry eye syndrome, Asthma)
  • Thorough QT studies
  • Microdosing/microtracing studies (Absolute bioavailability, Human mass balance, PET-imaging)
  • Multi-ethnic pharmacokinetic studies
  • Bridging studies
  • Genotype-based PK studies
주요연구 실적
  • Choi YJ, Lee HY, Yoon D, Kim A, Shin YS, Park HS, Ye YM. Trabecular Bone Score Is More Sensitive to Asthma Severity and Glucocorticoid Treatment Than Bone Mineral Density in Asthmatics. Allergy Asthma Immunol Res. 2019 May;11(3):343-356. PubMed PMID: 30912324
  • Kim E, Kim A, Yi S, Kim YK, Jang SB, Byun HM, Yoon SH, Cho JY, Jang IJ, Yu KS, Lee S. Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects. Eur J Clin Pharmacol. 2018 Oct;74(10):1261-1272. PubMed PMID: 29907887
  • Choi Y, Lee SW, Kim A, Jang K, Nam H, Cho YL, Yu KS, Jang IJ, Chung JY. Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects. J Antimicrob Chemother. 2018 Jan 1;73(1):183-190. PubMed PMID: 29069400
  • Oh J, Lee S, Kim A, Yoon J, Jang K, Lee DH, Cho S, Lee SR, Yu KS, Chung JY. Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study. J Clin Pharmacol. 2018 Jan;58(1):64-73. PubMed PMID: 28815639
  • Kim, Y. K., Kim A, Park S.J., Lee H. New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients. Drug Des Devel Ther. 2017 Sep 28;11:2861-2869. PubMed PMID: 29033547
  • Kim Y, Kim A, Lee S, Choi SH, Lee DY, Song JS, Lee H, Jang IJ, Yu KS. Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate After Single-Dose Administration in Healthy Korean Male Subjects. Clin Ther. 2017 Sep;39(9):1849-1857. PubMed PMID: 28865799
  • Kim A, Yu BY, Dueker SR, Shin KH, Kim HS, Ahn H, Cho JY, Yu KS, Jang IJ, Lee H. An accelerator mass spectrometry-enabled microtracer study to evaluate the first-pass effect on the absorption of YH4808. Clin Pharmacol Ther. 2017 Sep;102(3):537-546. Epub 2017 May 26. PubMed PMID: 28214288
  • Chung H, Kim A, Lim KS, Park SI, Yu KS, Yoon SH, Cho JY, Chung JY. Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults. Int Clin Psychopharmacol. 2017 Jan;32(1):20-26. PubMed PMID: 27741028
  • Park SI, An H, Kim A, Jang IJ, Yu KS, Chung JY. An analysis of QTc prolongation with atypical antipsychotic medications and selective serotonin reuptake inhibitors using a large ECG record database. Expert Opin Drug Saf. 2016 Aug;15(8):1013-9. Epub 2016 Jun 22. PubMed PMID: 27276059
  • Kim A, Lee J, Shin D, Jung YJ, Bahng MY, Cho JY, Jang IJ. Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment. Br J Clin Pharmacol. 2016 Aug;82(2):389-98. Epub 2016 Jun 3. PubMed PMID: 27084997
  • Kim A, Lim KS, Lee H, Chung H, Yoon SH, Yu K-S, Cho J-Y, Jang I-J, Chung J-Y. A thorough QT study to evaluate the QTc prolongation potential of two neuropsychiatric drugs, quetiapine and escitalopram, in healthy volunteers. Int Clin Psychopharmacol. 2016 Jul;31(4):210-7. Epub 2016 Mar 4. PubMed PMID: 26950553
  • Oh J, Chung H, Park SI, Yi SJ, Jang K, Kim A, Yoon J, Cho JY, Yoon SH, Jang IJ, Yu KS, Chung JY. Inhibition of the multidrug and toxin extrusion (MATE) transporter by pyrimethamine increases the plasma concentration of metformin but does not increase antihyperglycaemic activity in humans. Diabetes Obes Metab. 2016 Jan;18(1):104-8. Epub 2015 Oct 26. PubMed PMID: 26381793.
  • Lee J, Kim A, Yu KS, Chung JY, Yim SV, Kim BH. Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers. TCP | v.23, no.2, pp.49-53, Dec, 2015.
  • Kim A, Chung I, Yoon SH, Yu KS, Lim KS, Cho JY, Lee H, Jang IJ, Chung JY. Effects of Proton Pump Inhibitors on Metformin Pharmacokinetics and Pharmacodynamics. Drug Metab Dispos 42:1174–1179, July 2014. PubMed PMID: 24764147
  • Kim A, Kim BH, Shin DS, Choo JY, Yu KS, Jang IJ, Chung JY. Pharmacokinetics, Pharmacodynamics and Safety of JES9501 after Single and Multiple Oral Administration in Healthy Subjects. J Korean Soc Clin Pharmacol Ther | v.21, no.2, pp.141-149, Dec, 2013